22H041  邵晓奇，蔡平东，张越(广东药科大学).Infarction or reperfusion-induced cardiac autophagy: role of microRNAs（梗死或再灌注诱导的心脏自噬：microRNA的作用）

[摘要]心肌梗死（MI）期间，心肌细胞死亡的过程是由长时间心脏缺血触发的。近年来，非编码RNA在心血管疾病病理生理学中的作用越来越重要。被称为microRNA（miRNA）的RNA分子是小的非编码RNA，其表达在不同器官中有所不同。microRNA在与自噬相关的过程中发挥重要作用，自噬有助于心力衰竭的发展。这些过程包括调节线粒体完整性和功能、抗氧化防御、氧化应激、铁超载、铁死亡和生存途径。microRNA可以作为治疗心血管疾病的有前途的生物标志物和有用靶点。对于新靶向药物的开发，揭示microRNA表达如何变化及其如何调节自噬至关重要。为了理解心肌梗死和缺血再灌注损伤的机制，了解这2个过程之间的相互关系至关重要。这篇综述将简要介绍microRNA、自噬以及与microRNA相关的药物。

[关键词]心肌梗死/再灌注损伤; 自噬; 微小RNA

[Abstract] The process of cardiomyocyte death is triggered by prolonged ischemia in the heart during myocardial infarction (MI). And the role of non-coding RNAs in the pathophysiology of cardiovascular diseases has become increasingly important in recent years. RNA molecules known as microRNAs (miRNAs) are small non-coding RNAs whose expression varies across organs. microRNAs play an important role in processes associated with autophagy, which contribute to the development of heart failure. These processes include mitochondrial integrity and function, antioxidant defense, oxidative stress, iron overload, ferroptosis, and survival pathways. microRNAs may serve as promising biomarkers and useful targets in the treatment of cardiovascular disease. For the development of new targeted drugs, it is vital to uncover how microRNA expression changes and how they regulate autophagy. In order to comprehend the mechanisms of myocardial infarction and ischemic reperfusion injury, it is crucial to understand how these two processes relate to each other. In this review, we will provide a brief introduction to microRNAs, autophagy, and associated medicine to microRNAs.

[Key words] Myocardial infarction/reperfusion injury; Autophagy; MicroRNA